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KMID : 1123920200340050238
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Korean Journal of Oriental Physiology and Pathology
2020 Volume.34 No. 5 p.238 ~ p.244
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Studies on Anti-inflammatory Effects of Yangdan-tang Extracts
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Choi Su-Ryeon
Hwang Hyung-Seo
Kim Tae-Yeon
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Abstract
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Yangdan-tang (YD) is recorded as a treatment to treat exterior-related fever illness in the Korean medicine. In this study, we examined the anti-inflammatory effects of YD, using YD water extract and lipopolysaccharide (LPS)-induced RAW 264.7 cells. First of all, we measured the amount of nitric oxide (NO) and prostaglandin E2 (PGE2), the products of inflammatory metabolism. Also, we measured enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1 alpha (IL-1α), and interleukin 1 beta (IL-1β). YD suppressed the production of NO and PGE2 in a dose dependent manner and reduced the amount of protein and the mRNA expression of iNOS and COX-2. Also, YD reduced the mRNA expression of TNF-α, IL-6, IL-1α and IL-1β. In conclusion, YD decreased production of LPS-induced inflammatory factor, which could be a clinical basic subject for inflammatory diseases.
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KEYWORD
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Yangdan-tang (YD)(陽旦湯), Anti-inflammatory, Inflammatory factor, NO, PGE2
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